Toxicity of White Turi Leaf Extract on Liver Function in Mice
Toksisitas Ekstrak Daun Turi Putih pada Fungsi Hati Mencit
DOI:
https://doi.org/10.21070/how.v2i3.255Keywords:
Sesbania Grandiflora, White Turi Leaf, SGOT, SGPT, HepatotoxicityAbstract
General background: Sesbania grandiflora (L.) Pers., widely known as white turi, is traditionally used as analgesic, laxative, and other medicinal purposes. Specific background: Despite its therapeutic benefits, the plant contains secondary metabolites, including triterpenoids and alkaloids, with potential hepatotoxic properties, particularly pyrrolizidine alkaloids. Knowledge gap: Previous studies have indicated general toxicity of turi extracts but limited evidence exists on its subacute hepatic toxicity measured through enzymatic markers in animal models. Aim: This study investigated the toxicity of white turi leaf extract on liver function by assessing SGOT and SGPT levels in mice (Mus musculus). Results: Laboratory experiments using a posttest-only control group design were conducted with multiple dosage levels. Statistical analysis with Kruskal-Wallis revealed no significant differences in SGOT (p = 0.896) and SGPT (p = 0.527) levels between treatment and control groups, while ANOVA showed no significant change in liver weight (p = 0.089). Novelty: This research provides the first evidence that ethanolic white turi leaf extract, within the tested doses and 14-day observation, does not induce measurable hepatic dysfunction in mice. Implications: The findings suggest relative safety of white turi extract at tested doses, supporting its potential traditional use while highlighting the importance of further chronic toxicity studies.
Highlights :
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White turi leaf extract showed no hepatotoxic effect in mice.
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SGOT-SGPT levels and liver weight remained within normal range.
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Supports safe traditional use but requires chronic toxicity evaluation.
Keywords : Sesbania Grandiflora, White Turi Leaf, SGOT, SGPT, Hepatotoxicity
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